Anton Smith et al, J Adv Scient Res, 2011; 2(4): 12-19
Journal of Advanced Scientific Research
Available online through http://www.sciensage.info/jasr
Nanoparticles – A Review
G.Maruthi, A.Anton Smith*, R.Manavalan
Department of Pharmacy, Annamalai University, Annamalai Nagar-608 002, Tamilnadu *Corresponding author: email@example.com ABSTRACT For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmaco-dynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes. Keywords: Nano-particles, Drug delivery, Targeting drug release
Nanotechnology in short nanotech is the study of controlling of matter on anatomic size 100nm or even smaller in at least one dimension. It involves in developing sophisticated materials or devices with in that size. Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 10/1000nm. The drug is dissolved, entrapped, encapsulated or attached to nanoparticle matrix. Depending upon the method of preparation, nanoparticles, Nano-spheres or Nano-capsules can be obtained. Nano-capsules are systems in which the drug is confined to a...