Effects of Antidepressants
Ashley Tankersley, period 5
Antidepressants are widely used for treatment of depression. In fact, they are the most prescribed medication in the U.S. The most common antidepressants prescribed is Cymbalta according to Snared by Rebecca Terrell (2014). Also, most antidepressants prescribed are second generation and are used to treat more than just MDD (Major Depression Disorder), like anxiety. While a huge percentage of Americans take antidepressants, most don't know the effects of them.
In Gartlehner at al. (2011)'s study on second generation antidepressants, they took a group of adults, ages 19 and up that speak English, and did trials containing thirteen second-generation antidepressants: fluvoxamine, mirtazapine, bupropion, citalopram, desvenlafaxine, duloxetine, escitalopram, fluoxetine, , nefazodone, paroxetine, sertraline, trazodone, venlafaxine, and all of their trade names. They conducted a six-week-long trial that compared two drugs that were completely randomized with follow-up of 12 weeks. There were 1000 participants. All of the trials that were of poor quality or risk of bias was excluded from results.
The results show overall that there wasn't many differences in effectiveness or efficiency. Also, 37% of patients did not receive a response for six to twelve weeks. (Gartlehner et al., 2011) Escitalopram had a greater response time than citalopram. Same for sertraline over fluoxetine and venlafaxine over fluoxetine. There was also no differences in health-related quality of life. (Gartlehner et al., 2011) With the second-generation antidepressants, less than half of the patients did not receive a response at all and over half of the patients did not achieve remission. Surprisingly, comparative results for depression and insomnia, depression and low energy, depression and melancholia, depression and pain, depression and psychomotor, and depression and...