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Aminoglycosides Essay

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Below is an essay on "Aminoglycosides" from Anti Essays, your source for research papers, essays, and term paper examples.

  * Streptomycin sulfate which is the first aminoglycoside available for clinical use derived from the bacterium Streptomyces griseus in 1944.
  * Inhibition of bacterial protein synthesis; actericidal effect

  * Aminoglycosides are for serious infections, and currently used to treat pseudomonas aeruginosa infection include gentamicin, tobramycin, and amikacin.
  * The aminoglycoside antibiotics are used against gram-negative bacteria such as E. coli, proteus spp., and pseudomonas spp. Som gram-positive cocci are resistant to aminoglycosides, so penicillins or cephalosporins may be used. However, aminoglycosides are not effective in treating MRSA.
  * They are almost exclusively used to treat gram negative infections but are also used in lower doses in addition to beta lactams (ie. nafcillin) to provide a synergistic effect.
  * A common place for this is in the treatment of endocarditis. Clinical application: to treat bacteremia, endocarditis, health-care and nosocomial pneumonias, intra-abdominal infections, and others.
  * In combination with gentamicin or streptomycin, penicillin G and ampicillin facilitate the intracellular uptake of the aminoglycoside, which causes the subsequent bactericidal effect against the enterococci.
  * Amikacin sulfate (Amikin): effective against gram-negative bacteria, including those resistant to other aminoglycosides. Used for respiratory tract, bone joint, skin, and soft-tissue infections.
  * Gentamicin sulfate (Ganamycin): To treat serious infections caused by gram-negative organisms (e.g., Pseudomonas aeruginosa, Proteus); to trat pelvic inflammatory disease; effective against methicillin-resistant Staphylococcus aureus infections.
  * Kanamycin sulfate (Kantrex): used orally for hepatic coma. Effective against gram-negative bacteria with the exception of Pseudomonas aeruginosa.
  * Neomycin sulfate Myciguent (Neo-Fradin): decreases bacteria in the...

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